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Tomoyuki Ohba, Yujiro Ariga, Takashi Maruyama, Nha K. Truong, Jun-ichiro Inoue and Tatsushi Muta Identification of interleukin-1 receptor-associated kinase 1 as a critical component that induces post-transcriptional activation of IκB-ζ The FEBS Journal 279

Version of Record online: 30 NOV 2011 | DOI: 10.1111/j.1742-4658.2011.08416.x

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IκB-ζ, an essential inflammatory regulator, is specifically induced by Toll-like receptor ligands or interleukin-1β by post-transcriptional activation via a 165-nucleotide element in IκB-ζ mRNA. Here, we found that while either IRAK1/4 or TRAF6 induces NF-κB activation, activation of IRAK1/4, but not that of TRAF6, are sufficient to elicit the post-transcriptional activation of IκB-ζ, suggesting a new pathway activated by IRAK1.

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