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Ryutaro Asano, Makoto Nakayama, Hiroko Kawaguchi, Tsuguo Kubota, Takeshi Nakanishi, Mitsuo Umetsu, Hiroki Hayashi, Yu Katayose, Michiaki Unno, Toshio Kudo and Izumi Kumagai Construction and humanization of a functional bispecific EGFR × CD16 diabody using a refolding system The FEBS Journal 279

Version of Record online: 6 DEC 2011 | DOI: 10.1111/j.1742-4658.2011.08417.x

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To restore growth inhibitory activity of a humanized bispecific EGFR × CD16 diabody (hEx16), we efficiently prepared 15 different hEx16 mutants by using a proven in vitro refolding method. Some mutants showed a recovery of binding strength to over 10 times the original strength of hEx16 and the cancer cell growth inhibition was also restored for several mutants.

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