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Ram G. Nitharwal, Vijay Verma, Naidu Subbarao, Santanu Dasgupta, Nirupam R. Choudhury and Suman K. Dhar DNA binding activity of Helicobacter pylori DnaB helicase: the role of the N-terminal domain in modulating DNA binding activities FEBS Journal 279

Article first published online: 9 DEC 2011 | DOI: 10.1111/j.1742-4658.2011.08418.x

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In this study, we have analysed the DNA binding activity of H. pylori replicative helicase, DnaB. While the C-terminal region of HpDnaB is important for its DNA binding activity, the N-terminus masks the DNA binding activity profoundly. The masking effect can be overcome either by deleting the N-terminus or by interaction with a partner like the C-terminus of DnaG primase.

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