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Olga Tsaplina, Tatiana Efremova, Ilya Demidyuk and Sofia Khaitlina Filamentous actin is a substrate for protealysin, a metalloprotease of invasive Serratia proteamaculans The FEBS Journal 279

Version of Record online: 30 NOV 2011 | DOI: 10.1111/j.1742-4658.2011.08420.x

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Homologous bacterial metalloproteases ECP32/grimelysin from Serratia grimesii and protealysin from Serratia proteamaculans are involved in the invasion of those non-pathogenic bacteria in eukaryotic cells. Using anti-protealysin antibodies, we show that invasion of both S. proteamaculans and recombinant E. coli synthesizing protealysin is accompanied by translocation of the enzyme into 3T3-SV40 cells. Furthermore, protealysin limitedly cleaves F-actin efficiently enhancing actin dynamics.

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