E-mail

E-mail a Wiley Online Library Link

Olga Tsaplina, Tatiana Efremova, Ilya Demidyuk and Sofia Khaitlina Filamentous actin is a substrate for protealysin, a metalloprotease of invasive Serratia proteamaculans The FEBS Journal 279

Version of Record online: 30 NOV 2011 | DOI: 10.1111/j.1742-4658.2011.08420.x

Thumbnail image of graphical abstract

Homologous bacterial metalloproteases ECP32/grimelysin from Serratia grimesii and protealysin from Serratia proteamaculans are involved in the invasion of those non-pathogenic bacteria in eukaryotic cells. Using anti-protealysin antibodies, we show that invasion of both S. proteamaculans and recombinant E. coli synthesizing protealysin is accompanied by translocation of the enzyme into 3T3-SV40 cells. Furthermore, protealysin limitedly cleaves F-actin efficiently enhancing actin dynamics.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

SEARCH