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Gregor Lorbek, Monika Lewinska and Damjana Rozman Cytochrome P450s in the synthesis of cholesterol and bile acids – from mouse models to human diseases The FEBS Journal 279

Version of Record online: 22 DEC 2011 | DOI: 10.1111/j.1742-4658.2011.08432.x

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This review describes the transgenic mouse models designed to evaluate the functions of cytochromes P450 of cholesterol synthesis (CYP51) and bile acid synthesis (CYPs of families 7,8,27,39,46), and their link to disease. Despite important physiological differences between humans and mice, mouse models prove to be invaluable tools in understanding the multifactorial facets of cholesterol and bile acid related disorders.

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