Christopher R. Pudney, Derren J. Heyes, Basile Khara, Sam Hay, Stephen E. J. Rigby and Nigel S. Scrutton Kinetic and spectroscopic probes of motions and catalysis in the cytochrome P450 reductase family of enzymes The FEBS Journal 279
The diflavin oxidoreductase family of flavoproteins are electron transferases that transfer electrons to a variety of downstream redox partner proteins. The mechanism of electron transfer is linked to domain motion. We review here the biophysical and structural studies that have revealed major insight into these conformationally coupled electron transfer reactions.
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