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Yoko Chiba, Tohru Terada, Masafumi Kameya, Kentaro Shimizu, Hiroyuki Arai, Masaharu Ishii and Yasuo Igarashi Mechanism for folate-independent aldolase reaction catalyzed by serine hydroxymethyltransferase The FEBS Journal 279

Version of Record online: 23 DEC 2011 | DOI: 10.1111/j.1742-4658.2011.08443.x

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Serine hydroxymethyltransferase catalyzes the cleavage of various β-hydroxyamino acids into glycine and aldehydes in the absence of tetrahydrofolate. The reaction rate varies depending on the substituent and stereochemistry at the Cβ atom. We present a unified model to explain the origin of the substituent and stereochemical preferences by combining the theoretical and experimental results

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