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Suzy C. Moody, Bin Zhao, Li Lei, David R. Nelson, Jonathan G. L. Mullins, Michael R. Waterman, Steven L. Kelly and David C. Lamb Investigating conservation of the albaflavenone biosynthetic pathway and CYP170 bifunctionality in streptomycetes The FEBS Journal 279

Version of Record online: 27 JAN 2012 | DOI: 10.1111/j.1742-4658.2011.08447.x

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The characterization of S. albus CYP170B1 validated this enzyme as an albaflaveone synthase. However, in contrast to the bifunctional CYP170A1 from S. coelicolor A3(2), CYP170B1 was unable to catalyze the conversion of FPP to farnesene. We propose that absence of key amino acid residues in binding the essential terpene synthase cofactor Mg2+ is the explanation for loss of CYP170B1 bifunctionality.

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