E-mail a Wiley Online Library Link

Susana R. Pereira, Vítor M. Vasconcelos and Agostinho Antunes Computational study of the covalent bonding of microcystins to cysteine residues – a reaction involved in the inhibition of the PPP family of protein phosphatases FEBS Journal 280

Article first published online: 9 JAN 2012 | DOI: 10.1111/j.1742-4658.2011.08454.x

Thumbnail image of graphical abstract

Microcystins are cyanobacterial hepatotoxins that inhibit serine/threonine-specific protein phosphatases of the PPP family. This often involves covalent-bonding to a PPP cysteine residue. Here, the molecular interaction of microcystins with the targeted PPP enzymes is reviewed, including the relevance of the covalent bond for overall inhibition. Additionally, the formation of the covalent bond was evaluated in silico, using quantum mechanical-based methods.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field