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Igor F. Tsigelny, Yuriy Sharikov, Wolfgang Wrasidlo, Tania Gonzalez, Paula A. Desplats, Leslie Crews, Brian Spencer and Eliezer Masliah Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation The FEBS Journal 279

Version of Record online: 27 FEB 2012 | DOI: 10.1111/j.1742-4658.2012.08489.x

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We utilized computer modeling and cell-based studies to study α-synuclein (α-syn) oligomerization in membranes. The studies suggest that α-syn penetrates the membrane facilitating the incorporation of additional α-syn monomers to the complex, and subsequent displacement of phospholipids, and formation of annular oligomers in the membrane. This process occurred more rapidly for mutant A53T compared with wild-type α-syn.

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