Andrea Kiss, Bálint Bécsi, Bernadett Kolozsvári, István Komáromi, Katalin E. Kövér and Ferenc Erdődi Epigallocatechin-3-gallate and penta-O-galloyl-β-d-glucose inhibit protein phosphatase-1 The FEBS Journal 280
Polyphenolic EGCG and PGG are partially selective inhibitors of protein phosphatase–1 (PP1). The galloyl group in the polyphenols plays a major role in phosphatase inhibition. Molecular docking predicts that EGCG binds to part of the hydrophobic groove at the catalytic center of PP1 catalytic subunit. The PP1 inhibitory features of the polyphenols might be implicated in their cell death inducing effects.
Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf