Andrea Kiss, Bálint Bécsi, Bernadett Kolozsvári, István Komáromi, Katalin E. Kövér and Ferenc Erdődi Epigallocatechin-3-gallate and penta-O-galloyl-β-d-glucose inhibit protein phosphatase-1 FEBS Journal 280
Article first published online: 13 FEB 2012 | DOI: 10.1111/j.1742-4658.2012.08498.x
Polyphenolic EGCG and PGG are partially selective inhibitors of protein phosphatase–1 (PP1). The galloyl group in the polyphenols plays a major role in phosphatase inhibition. Molecular docking predicts that EGCG binds to part of the hydrophobic groove at the catalytic center of PP1 catalytic subunit. The PP1 inhibitory features of the polyphenols might be implicated in their cell death inducing effects.
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