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Victoria Kolupaeva and Veerle Janssens PP1 and PP2A phosphatases – cooperating partners in modulating retinoblastoma protein activation The FEBS Journal 280

Version of Record online: 29 FEB 2012 | DOI: 10.1111/j.1742-4658.2012.08511.x

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The family of retinoblastoma (Rb) proteins regulates the cell cycle by controlling activity of the E2F family of transcription factors. The activity of Rb proteins themselves is modulated by their phosphorylation status. This review focuses on PP1 and PP2A phosphatases that are responsible for dephosphorylation and thus activation of Rb. Modulation of Rb proteins activity by both phosphatases is highly context-dependent.

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