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Lan K. Nguyen, David Matallanas, David R. Croucher, Alexander von Kriegsheim and Boris N. Kholodenko Signalling by protein phosphatases and drug development: a systems-centred view The FEBS Journal 280

Version of Record online: 14 MAR 2012 | DOI: 10.1111/j.1742-4658.2012.08522.x

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Emerging evidence suggests that phosphatase kinetics are critical for the network function and cell-fate decisions. Protein phosphatases can operate as both immediate and delayed regulators of signal transduction, capable of attenuating or amplifying signaling. This versatility of phosphatase action emphasizes the need for systems biology approaches to comprehend cellular signaling networks and predict the cellular outcomes of combinatorial drug interventions.

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