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Verónica Barrioluengo, Yi Wang, Stuart F. J. Le Grice and Luis Menéndez-Arias Intrinsic DNA synthesis fidelity of xenotropic murine leukemia virus-related virus reverse transcriptase The FEBS Journal 279

Version of Record online: 16 MAR 2012 | DOI: 10.1111/j.1742-4658.2012.08532.x

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Pre-steady-state kinetics of nucleotide incorporation and M13mp2-based forward mutation assays were used to determine the accuracy of XMRV and Moloney murine leukemia virus (MoMLV) reverse transcriptases (RTs). Both polymerases showed higher fidelity than the HIV-1BH10 RT. XMRV and MoMLV RTs showed differences in extension efficiencies for specific mispairs and in their ability to introduce frameshifts and large deletions

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