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Pavel Tsaytler and Anne Bertolotti Exploiting the selectivity of protein phosphatase 1 for pharmacological intervention FEBS Journal 280

Article first published online: 14 MAR 2012 | DOI: 10.1111/j.1742-4658.2012.08535.x

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Selective and reversible phosphorylation is one of the most common post-translational modifications of proteins. While kinase inhibitors are popular in drug development programs, selective pharmacological manipulation of phosphatase activity has been challenging to achieve. Here we review recent advances in the development of selective inhibitors of dephosphorylation events and discuss the potential applications of small-molecule phosphatase inhibitors.

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