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Tony Tiganis PTP1B and TCPTP – nonredundant phosphatases in insulin signaling and glucose homeostasis The FEBS Journal 280

Version of Record online: 18 APR 2012 | DOI: 10.1111/j.1742-4658.2012.08563.x

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PTP1B and TCPTP are closely related classical tyrosine-specific protein tyrosine phosphatases (PTPs). In this review I will highlight their capacity to act specifically and non-redundantly in cellular signaling, describe their roles in insulin signaling and glucose homeostasis, and discuss their potential as drug targets for the enhancement of insulin receptor phosphorylation and insulin sensitivity in type 2 diabetes.

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