Ward Sents, Elitsa Ivanova, Caroline Lambrecht, Dorien Haesen and Veerle Janssens The biogenesis of active protein phosphatase 2A holoenzymes: a tightly regulated process creating phosphatase specificity FEBS Journal 280
Article first published online: 25 APR 2012 | DOI: 10.1111/j.1742-4658.2012.08579.x
Protein phosphatase 2A (PP2A) specificity is largely determined by the particular subunit composition of the holoenzyme. The biogenesis of these holoenzymes is a complicated process, tightly controlled by a sophisticatedly coordinated network of five PP2A modulators, consisting of α4, PTPA, LCMT1, PME-1 and potentially TIPRL1. Although less clear, the biogenesis of the PP2A-like phosphatases PP4 and PP6 may prove to be highly similar.
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