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Kelly A. Pike and Michel L. Tremblay Regulating naïve and memory CD8 T cell homeostasis – a role for protein tyrosine phosphatases FEBS Journal 280

Article first published online: 24 APR 2012 | DOI: 10.1111/j.1742-4658.2012.08587.x

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CD8 T cell homeostasis is primarily regulated by signalling events downstream of the T cell receptor complex and common γ chain cytokine receptors. Such signaling events are propagated by phosphorylation and dephosphorylation of tyrosine residues by protein tyrosine kinase and phosphatases. The contribution of protein tyrosine phosphatases to CD8 T cell maintenance, and as a consequence immunological health, is discussed.

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