David L. Brautigan Protein Ser/ Thr phosphatases – the ugly ducklings of cell signalling The FEBS Journal 280
This article traces historical origins leading to the current state of knowledge of protein Ser/Thr phosphatases, starting with the ‘PR Enzyme’ discovered by Gerty and Carl Cori. Regulation and specificity are achieved through assembly of multisubunitholoenzymes, transient phosphorylation and the action of inhibitor proteins. There are hundreds of discrete protein Ser/Thr phosphatases to counteract protein kinases, offering potential therapeutic targets and new components for signaling networks and modeling schemes.
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