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Francesco Paduano, Vincenzo Dattilo, Domenico Narciso, Anna Bilotta, Eugenio Gaudio, Miranda Menniti, Valter Agosti, Camillo Palmieri, Nicola Perrotti, Alfredo Fusco, Francesco Trapasso and Rodolfo Iuliano Protein tyrosine phosphatase PTPRJ is negatively regulated by microRNA-328 The FEBS Journal 280

Version of Record online: 30 MAY 2012 | DOI: 10.1111/j.1742-4658.2012.08624.x

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We identified a novel mechanism of regulation of PTPRJ expression. Here, overexpression of miR-328 decreased both protein and mRNA levels of PTPRJ in HeLa and SKBr3 cells. PTPRJ was assessed to be a direct target and functional target gene of miR-328. We propose that this interaction is responsible for the miR-328-dependent increase of epithelial cellular proliferation.

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