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Robert Karisch and Benjamin G. Neel Methods to monitor classical protein-tyrosine phosphatase oxidation The FEBS Journal 280

Version of Record online: 30 MAY 2012 | DOI: 10.1111/j.1742-4658.2012.08626.x

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Reversible oxidation, which inactivates PTPs, is emerging as an important cellular regulatory mechanism and contributes to human diseases, including cancer. Identifying ROS-inactivated PTPs could be tantamount to finding the PTP(s) that critically regulate a specific signaling pathway. This article provides an overview of the methods currently available to identify and quantify PTP oxidation and outlines future challenges in redox signaling.

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