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Claudio R. Santos and Almut Schulze Lipid metabolism in cancer The FEBS Journal 279

Version of Record online: 3 JUL 2012 | DOI: 10.1111/j.1742-4658.2012.08644.x

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The availability of lipids in cancer cells is increased due to stimulation of de novo synthesis by oncogenic signalling and increased uptake from the blood stream. Lipids may contribute to several aspects of the tumour phenotype such as growth and proliferation or survival under oxidative and energy stress. Additionally, lipids also stimulate signalling pathways that lead to proliferation and invasion

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