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Peter Buske, Jens Przybilla, Markus Loeffler, Norman Sachs, Toshiro Sato, Hans Clevers and Joerg Galle On the biomechanics of stem cell niche formation in the gut – modelling growing organoids The FEBS Journal 279

Version of Record online: 18 JUN 2012 | DOI: 10.1111/j.1742-4658.2012.08646.x

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Intestinal organoids grow from single Lgr5-positive stem cells. We introduce a single cell-based computer model of these systems. In simulation studies, we find that proliferation-induced shape fluctuations are sufficient to induce crypt-like domains. Moreover, assuming that stem cell differentiation is triggered by local tissue curvature, stem cell expansion within the organoids sensitively depends on tissue biomechanics

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