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Frank Böhmer, Stefan Szedlacsek, Lydia Tabernero, Arne Östman and Jeroen den Hertog Protein tyrosine phosphatase structure–function relationships in regulation and pathogenesis FEBS Journal 280

Article first published online: 2 JUL 2012 | DOI: 10.1111/j.1742-4658.2012.08655.x

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Protein phosphorylation on tyrosine residues is tightly controlled by protein tyrosine phosphatases (PTPs). Understanding the structure-function relationship in PTPs is of fundamental importance to dissect their roles in health and disease. This review focuses on regulation of receptor-like PTPs by extracellular ligands, on regulation of PTPs by oxidation and on structural features of pathogenic PTPs.

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