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Feng Yang, Jianwei Bi, Xuchao Xue, Luming Zheng, Kangkang Zhi, Jide Hua and Guoen Fang Up-regulated long non-coding RNA H19 contributes to proliferation of gastric cancer cells The FEBS Journal 279

Version of Record online: 31 JUL 2012 | DOI: 10.1111/j.1742-4658.2012.08694.x

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The expression of long non-coding RNA H19 was markedly increased in gastric cancer cells and tissues compared with normal controls. In AGS human gastric cancer cell lines, ectopic expression of H19 increased proliferation, whereas H19-siRNA treatment contributed to apoptosis. H19 was associated with and partially inactivated p53. Thus, H19 seems to play an important role in gastric cancer and has potential as a therapeutic

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