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Krisztina Matúz, János Mótyán, Mi Li, Alexander Wlodawer and József Tőzsér Inhibition of XMRV and HIV-1 proteases by pepstatin A and acetyl-pepstatin The FEBS Journal 279

Version of Record online: 17 AUG 2012 | DOI: 10.1111/j.1742-4658.2012.08714.x

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The kinetic properties of pepstatin A and acetyl-pepstatin were compared with respect to their interactions with HIV-1 and XMRV proteases. Enzyme-inhibitor interaction energies were calculated and dimerization was investigated. The crystal structure of acetyl-pepstatin/XMRV protease complex was solved and showed a mixed type of binding

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