Maria V. Verga Falzacappa, Chiara Ronchini, Linsey B. Reavie and Pier G. Pelicci Regulation of self-renewal in normal and cancer stem cells FEBS Journal 279
Article first published online: 24 AUG 2012 | DOI: 10.1111/j.1742-4658.2012.08727.x
It has been shown that only a small sub-population of cells, the cancer stem cells (CSCs), is necessary and sufficient to originate a tumour. We discuss how, compared to normal SCs, CSCs exhibit a profound de-regulation of their self-renewal capability, mainly due to differences in mode of division, cell-cycle properties, replicative potential and handling of DNA-damage.
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