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Matt Gooding, Slavica Tudzarova, Roberta J. Worthington, Sarah R. Kingsbury, Anne-Sophie Rebstock, Henry Dube, Michela I. Simone, Cristina Visintin, Dimitris Lagos, Juan-Manuel Funes Quesada, Heike Laman, Chris Boshoff, Gareth H. Williams, Kai Stoeber and David L. Selwood Exploring the Interaction Between siRNA and the SMoC Biomolecule Transporters: Implications for Small Molecule–Mediated Delivery of siRNA Chemical Biology & Drug Design 79

Article first published online: 4 NOV 2011 | DOI: 10.1111/j.1747-0285.2011.01249.x

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Suzuki-Miyaura coupling utilising a Molander Aryl trifluoroborate salt allows a simple synthesis of SMoC biomolecule transporters. Molecular dynamics and NMR studies indicate formation of a π-cation interaction between a guanidine and the adjacent aryl ring. Complex formation with siRNA is controlled by enthalpic forces and allows cellular uptake and functional knockdown of Cdc7 kinase.

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