Mukesh Chourasia and G. Narahari Sastry The Nucleotide, Inhibitor, and Cation Binding Sites of P-type II ATPases Chemical Biology & Drug Design 79
Article first published online: 23 FEB 2012 | DOI: 10.1111/j.1747-0285.2012.01334.x
P-Type ATPases constitute a ubiquitous superfamilly of cation transport enzymes, responsible for carrying out actions of paramount importance in biology such as ion transport, and expulsion of toxic ions from cells etc. The harmonized toggling of gates in the extra and intracellular domains explains the phenomenon of specific cation binding in selective physiological states. The current review delineates the importance of cation, nucleotide and inhibitor binding domains, with a focus on the therapeutic potential and biological relevance of the three P-Type II ATPases.
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