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Vincent Murray, Trung V. Nguyen and Jon K. Chen The Use of Automated Sequencing Techniques to Investigate the Sequence Selectivity of DNA-Damaging Agents Chemical Biology & Drug Design 80

Version of Record online: 13 APR 2012 | DOI: 10.1111/j.1747-0285.2012.01379.x

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The use of automated DNA sequencing techniques to determine the sequence specificity of compounds that interact with DNA is reviewed. The sequence specificity of a DNA damaging agent is an essential element in determining the cellular mechanism of action of a drug. The current state-of-the-art methodology involves capillary electrophoresis with laser-induced fluorescence detection and has higher resolution, greater sensitivity, higher precision, more rapid separation times, is safer, and easier to perform than previous methods.

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