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Jothi Ramalingam, Jannet Vennila and Parthasarathy Subbiah Computational Studies on the Resistance of Penicillin-Binding Protein 2B (PBP2B) of Wild-type and Mutant Strains of Streptococcus pneumoniae Against β-Lactam Antibiotics Chemical Biology & Drug Design 82

Version of Record online: 24 JUL 2013 | DOI: 10.1111/j.1747-0285.2012.01387.x

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Computational studies on the resistance of PBP2B of Streptococcus pneumoniae clearly show that the wild type R6 as sensitive, mutant strains 5204 and G54 as highly resistant and Hungary19A-6 and SP195 as intermediate resistant. They also reveal that the mutant strains Hungary19A-6 and SP195 exhibit intermediate resistant due to the existence of mutations are only till the intermediate positions and show 1 that if the mutations are induced till C terminus end, then the antibiotic resistance increases from intermediate to high.

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