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Shantal Dorasamy, Nicolisha Narainpersad, Moganavelli Singh and Mario Ariatti Novel Targeted Liposomes Deliver siRNA to Hepatocellular Carcinoma Cells in vitro Chemical Biology & Drug Design 80

Article first published online: 3 SEP 2012 | DOI: 10.1111/j.1747-0285.2012.01446.x

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The d-galactopyranosyl ring in direct β-glycosidic link to cholesterol, when formulated into cationic liposomes with the cytofectin 3β[N-(N′,N′,N′,-trimethylammoniumpropane) carbamoyl] cholesterol iodide promotes efficient targeted delivery of a cytotoxic siRNA to the human hepatoblastoma cell line HepG2 via the asialoglycoprotein receptor (ASGP-R). However the receptor-negative human embryonic kidney cell line HEK293 is resistant to transfection under the same conditions.

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