Patricia Cramers, Alfred Ronald Filon, Alex Pines, Jos C. Kleinjans, Leon H. F. Mullenders and Albert A. van Zeeland Enhanced Nucleotide Excision Repair in Human Fibroblasts Pre-exposed to Ionizing Radiation Photochemistry and Photobiology 88
Article first published online: 17 NOV 2011 | DOI: 10.1111/j.1751-1097.2011.01019.x
Ionizing radiation mediated activation of the DNA damage response induces a transcriptional upregulation of genes that are also involved in nucleotide excision repair (NER). Here, we demonstrate in nondividing normal human fibroblasts that UV-induced NER is augmented by pre-exposure to IR. The increase of NER by IR lasts up to 48 h after X-ray treatment. Furthermore, we show by various approaches that both DDB2 and XPC play key roles in this adaptation process.
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