Stanley G. Kimani, James B. Phillips, James I. Bruce, Alexander J. MacRobert and Jon P. Golding Antioxidant Inhibitors Potentiate the Cytotoxicity of Photodynamic Therapy Photochemistry and Photobiology 88
Article first published online: 17 NOV 2011 | DOI: 10.1111/j.1751-1097.2011.01022.x
Photodynamic therapy (PDT) generates cytotoxic reactive oxygen species, which are partially neutralized by the major cellular antioxidant pathways (glutathione, superoxide dismutases and catalase). We find that pharmacological inhibition of selected antioxidant pathways, using combinations of four different inhibitors, strongly potentiates PDT cytotoxicity in MCF-7 cancer cells. The following antioxidant inhibitor combinations showed the greatest potentiation of PDT cell kill: BSO + 3AT > BSO + 2ME > 2ME + DDC > BSO + 3AT + 2ME + DDC > BSO > 2ME > 3AT > DDC.
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