E-mail a Wiley Online Library Link

Stanley G. Kimani, James B. Phillips, James I. Bruce, Alexander J. MacRobert and Jon P. Golding Antioxidant Inhibitors Potentiate the Cytotoxicity of Photodynamic Therapy Photochemistry and Photobiology 88

Article first published online: 17 NOV 2011 | DOI: 10.1111/j.1751-1097.2011.01022.x

Thumbnail image of graphical abstract

Photodynamic therapy (PDT) generates cytotoxic reactive oxygen species, which are partially neutralized by the major cellular antioxidant pathways (glutathione, superoxide dismutases and catalase). We find that pharmacological inhibition of selected antioxidant pathways, using combinations of four different inhibitors, strongly potentiates PDT cytotoxicity in MCF-7 cancer cells. The following antioxidant inhibitor combinations showed the greatest potentiation of PDT cell kill: BSO + 3AT > BSO + 2ME > 2ME + DDC > BSO + 3AT + 2ME + DDC > BSO > 2ME > 3AT > DDC.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

Choose captcha format: Image or Audio. Click here if you need help.