Reto Brem and Peter Karran Multiple forms of DNA Damage Caused by UVA Photoactivation of DNA 6-Thioguanine Photochemistry and Photobiology 88
Patients undergoing thiopurine immunosuppression or cancer treatment have 6-thioguanine in their DNA. This thio analog of guanine is a chromophore for ultraviolet A and when present in DNA it generates reactive oxygen species that damage DNA and protein. This photochemical damage includes the formation of inter- and intrastrand DNA crosslinks (1 & 2), DNA breakage (3), oxidation of DNA guanine (4) and 6-thioguanine (5) and the covalent attachment of protein to DNA (6). Some of the possible biological consequences of this damage, including a possible increased risk of skin cancer, are discussed.
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