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Sreekanth Narayanapillai, Chapla Agarwal, Cynthia Tilley and Rajesh Agarwal Silibinin Is a Potent Sensitizer of UVA Radiation-induced Oxidative Stress and Apoptosis in Human Keratinocyte HaCaT Cells† Photochemistry and Photobiology 88

Article first published online: 10 JAN 2012 | DOI: 10.1111/j.1751-1097.2011.01050.x

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UVA radiation causes significant damage to cellular components through the release of reactive oxygen species (ROS). We report that silibinin enhances UVA-induced ROS generation and apoptosis in human keratinocyte HaCaT cells. Furthermore, we found that silibinin enhances ER stress-mediated apoptosis in HaCaT cells by increasing the expression of CHOP protein. These results suggest that silibinin may be beneficial in the removal of UVA-damaged cells and the prevention of skin cancer.

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