Jean-Pierre Daziano, Wolfgang H.H. Günther, Marianne Krieg, Ichiro Tsujino, Kiyoko Miyagi, Gregory S. Anderson, Reynée W. Sampson, Martin D. Ostrowski, Sarah A. Muir, Raymond J. Bula and Fritz Sieber Photochemically Generated Elemental Selenium Forms Conjugates with Serum Proteins That Are Preferentially Cytotoxic to Leukemia and Selected Solid Tumor Cells Photochemistry and Photobiology 88
Version of Record online: 31 JAN 2012 | DOI: 10.1111/j.1751-1097.2012.01078.x
One-hour incubations with micromolar concentrations of selenomerocyanine-derived photoproducts reduce in vitro clonogenic wild-type leukemia cells (L1210) and melphalan-resistant leukemia cells (L1210/L-PAM1 and L1210/L-PAM2) by several orders of magnitude, but preserve virtually all normal CD34-positive normal bone marrow cells.
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