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Daniel Organisciak, Paul Wong, Christine Rapp, Ruth Darrow, Alison Ziesel, Rekha Rangarajan and John Lang Light-Induced Retinal Degeneration Is Prevented by Zinc, a Component in the Age-related Eye Disease Study Formulation† Photochemistry and Photobiology 88

Version of Record online: 30 MAR 2012 | DOI: 10.1111/j.1751-1097.2012.01134.x

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Rats were treated with various doses of zinc oxide and then exposed to intense visible light in a series of chambers like the one shown. Zinc treatment was effective in preventing retinal photoreceptor cell damage as determined by rhodopsin, retinal DNA recovery and retinal histology. Zinc was most effective when given before the onset of light and at doses slightly higher than found in the AREDS formulation. Zinc also altered the retinal gene expression profile, suggesting that it enhances antioxidative capacity in retina and that it reduces light-induced oxidative damage.

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