Yuan-Hao Lee, Neeru C. Kumar and Randolph D. Glickman Modulation of Photochemical Damage in Normal and Malignant Cells by Naturally Occurring Compounds† Photochemistry and Photobiology 88
Article first published online: 14 MAY 2012 | DOI: 10.1111/j.1751-1097.2012.01156.x
There is heightened interest in naturally occurring compounds as potential therapeutic agents. One such compound is ursolic acid (UA), a triterpenoid found in common foods such as cranberries, apples, as well as rosemary and other herbs. When skin melanoma (SM) cells are treated with UA, they become more susceptible to UV and visible light exposure, in contrast to normal phenotype retinal pigment epithelial (RPE) cells, whose sensitivity to light damage is unchanged by UA treatment. The figure shows the appearance of SM and RPE cells 24 h following light exposure with or without UA pretreatment.
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