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Albert R. Wielgus and Joan E. Roberts Retinal Photodamage by Endogenous and Xenobiotic Agents† Photochemistry and Photobiology 88

Version of Record online: 9 JUL 2012 | DOI: 10.1111/j.1751-1097.2012.01174.x

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The human eye is constantly exposed to sunlight and artificial lighting and this is fundamental to its unique biological functions of directing vision and circadian rhythm. However, after the age of 40, exposure to ambient radiation can pose an ocular hazard. There are age-related changes in the natural chromophores (lipofuscin, A2E and all-trans-retinal derivatives) in the human retina that makes it more susceptible to visible light damage. Drugs have the potential to induce photodamage to the retina. This article reviews the underlying reasons why short blue visible light dramatically raises the risk of photodamage to the human retina.

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