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Corinne Miquel-Jeanjean, Frédéric Crépel, Véronique Raufast, Bruno Payre, Lucien Datas, Sandrine Bessou-Touya and Hélène Duplan Penetration Study of Formulated Nanosized Titanium Dioxide in Models of Damaged and Sun-Irradiated Skins Photochemistry and Photobiology 88

Version of Record online: 9 JUL 2012 | DOI: 10.1111/j.1751-1097.2012.01181.x

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As suggested by the SCCS, dermal absorption of nanosized inorganic UV filters such as titanium dioxide (TiO2) was to be reconsidered by taking into account the possible impact of abnormal skin barrier function and UV radiation on skin penetration. Using intact, damaged, irradiated and damaged/irradiated pigskin explants reproducing the worse real-life conditions of sunscreen application, we demonstrated that nanosized TiO2 included in a sunscreen formed aggregates that remained in the uppermost layers of stratum corneum (SC), as shown by transmission electronic microscopy coupled with X-ray elemental analysis. Its bioavailability was not enhanced when skin barrier is first compromised, then submitted to solar radiation.

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