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Kathleen E. Wright, Alexander J. MacRobert and James B. Phillips Inhibition of Specific Cellular Antioxidant Pathways Increases the Sensitivity of Neurons to Meta-tetrahydroxyphenyl Chlorin-Mediated Photodynamic Therapy in a 3D Co-culture Model Photochemistry and Photobiology 88

Version of Record online: 9 JUL 2012 | DOI: 10.1111/j.1751-1097.2012.01185.x

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Inhibition of the endogenous antioxidants SOD-1 (A) or glutathione synthase (B) makes neurons susceptible to mTHPC-mediated PDT. Using a 3D co-culture model containing dorsal root ganglion neurons and glial cells, use of DDC or l-BSO to inhibit antioxidant activity resulted in decreased neuronal viability compared with controls that were not treated with the inhibitors (#P< 0.05, ##P < 0.01, ###P < 0.001) in which neurons survived mTHPC-mediated PDT.

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