Saveria Pastore, Daniela Lulli, Antonia Pascarella, Riccardo Maurelli, Elena Dellambra, Alla Potapovich, Vladimir Kostyuk, Chiara De Luca and Liudmila Korkina Resveratrol Enhances Solar UV-induced Responses in Normal Human Epidermal Keratinocytes Photochemistry and Photobiology 88
Article first published online: 8 AUG 2012 | DOI: 10.1111/j.1751-1097.2012.01195.x
Solar UV stimulates metabolic (Cyp1A1) and inflammatory (IL-8) responses of human epidermal keratinocytes through AhR and NFκB signal transduction pathways. FICZ, a product of tryptophan photo-oxidation, activates AhR-Cyp axis. Resveratrol (RV) stimulates both Cyp1A1 and IL-8 via AhR and RV-specific transcription factor (TF). Cooperative action of the transcription factors underlies synergic cellular responses to UV-RV or FICZ-RV combinations.
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