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Michelle Maclean, Lynne E. Murdoch, Scott J. MacGregor and John G. Anderson Sporicidal Effects of High-Intensity 405 nm Visible Light on Endospore-Forming Bacteria Photochemistry and Photobiology 89

Article first published online: 30 AUG 2012 | DOI: 10.1111/j.1751-1097.2012.01202.x

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This article investigates the susceptibility of Bacillus and Clostridium endospores to 405 nm light. Suspensions of B. cereus endospores were exposed to high-intensity 405 nm light and results demonstrated a sporicidal effect. Approximately a 4-log10 CFU mL−1 reduction in spore population was achieved after exposure to a dose of 1.73 kJ cm−2. Similar inactivation kinetics were demonstrated with B. subtilis, B. megaterium and C. difficile endospores. The doses required for endospore inactivation were significantly higher than those required for inactivation of vegetative cells. The demonstration that 405 nm visible light can inactivate endospores is significant, and could have potential for incorporation into decontamination methods. Associated figure: Figure 4 in the manuscript.

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