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Manoel Carneiro Oliveira-Junior, Aldaíza Salomão Monteiro, Ernesto César Pinto Leal-Junior, Egberto Munin, Rodrigo Aléxis Lazo Osório, Wellington Ribeiro and Rodolfo Paula Vieira Low-level Laser Therapy Ameliorates CCl4-induced Liver Cirrhosis in Rats Photochemistry and Photobiology 89

Article first published online: 18 SEP 2012 | DOI: 10.1111/j.1751-1097.2012.01211.x

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This study investigated the effects of low-level laser therapy (LLLT) in an experimental model of carbon tetrachloride (CCl4)-induced liver cirrhosis. A 830 nm LLLT applied for 2 weeks resulted in a significant reduction of CCl4-increased aspartate aminotransferase (P < 0.001), alkaline phosphatase (< 0.001), gamma-glutamyl transferase (P < 0.001), lactate dehydrogenase (P < 0.01), total proteins (P < 0.05) and globulins (P < 0.01). LLLT also reduced the number of cirrhotic areas, the collagen accumulation and the hepatic inflammatory infiltrate. LLLT also reduced CCl4-increased number of Kupffer cells (P < 0.05) and hepatic stellate cells (P < 0.05). LLLT presents beneficial effects on liver function and structure in an experimental model of CCl4-induced cirrhosis.

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