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Mari Sawamoto, Takafumi Imai, Mana Umeda, Koji Fukuda, Takao Kataoka and Shigeru Taketani The p53-Dependent Expression of Frataxin Controls 5-Aminolevulinic Acid-Induced Accumulation of Protoporphyrin IX and Photo-Damage in Cancerous Cells Photochemistry and Photobiology 89

Version of Record online: 13 SEP 2012 | DOI: 10.1111/j.1751-1097.2012.01215.x

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The expression of frataxin is dependent on the function of the tumor suppressor protein p53 at the transcriptional level. The knockdown of p53 by siRNA in HEK293T cells caused the decrease of the expression of frataxin, leading to enhancement of the ALA-induced accumulation of protoporphyrin. In contrast, overexpression of frataxin in human cancerous cells lowered the accumulation of protoporphyrin by up-regulation of mitochondrial functions and induced resistance to ALA-induced photo-damage, suggesting that dysfunction of p53 in tumor cells leads to the increase in the ALA-induced accumulation of protoporphyrin through the decrease of the expression of frataxin.

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