Emina Besic Gyenge, Daniel Lüscher, Patrick Forny, Martina Antoniol, Georg Geisberger, Heinrich Walt, Greta Patzke and Caroline Maake Photodynamic Mechanisms induced by a Combination of Hypericin and a Chlorin Based-Photosensitizer in Head and Neck Squamous Cell Carcinoma Cells Photochemistry and Photobiology 89
Article first published online: 13 SEP 2012 | DOI: 10.1111/j.1751-1097.2012.01217.x
Hypericin, liposomal mTHPC derivate and their 1:1 mixture mediated photodynamic therapy (PDT) effects were examined on head and neck squamous cell carcinoma cell lines. Our results showed that the application of photosensitizer mixtures with the features of reduced dark toxicity resulted in combined apoptotic and necrotic cell death.
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