WonBong Lim, JiSun Kim, SangWoo Kim, Sandeep Karna, JaeWoong Won, Sang Mi Jeon, Seo Yeon Kim, YooDuk Choi, HongRan Choi and OkJoon Kim Modulation of Lipopolysaccharide-Induced NF-κB Signaling Pathway by 635 nm Irradiation via Heat Shock Protein 27 in Human Gingival Fibroblast Cells Photochemistry and Photobiology 89
Article first published online: 18 SEP 2012 | DOI: 10.1111/j.1751-1097.2012.01225.x
Heat shock protein-27 (HSP27) is a member of the small HSP family, which has been linked to the nuclear factor-kappa B (NF-κB) signaling pathway regulating inflammatory responses. A lot of clinical reports have suggested that low-level light therapy/laser irradiation (LLLT) could be an effective alternative treatment to relieve inflammation during bacterial infection associated with periodontal disease. We examined whether 635 nm irradiation could lead to a modulation of the NF-B signaling pathway in HSP27-silenced cells and analyzed the functional cross-talk between these factors in NF-κB activation.
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