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Małgorzata Różanowska, Linda Bakker, Michael E. Boulton and Bartosz Różanowski Concentration Dependence of Vitamin C in Combinations with Vitamin E and Zeaxanthin on Light-Induced Toxicity to Retinal Pigment Epithelial Cells Photochemistry and Photobiology 88

Version of Record online: 1 OCT 2012 | DOI: 10.1111/j.1751-1097.2012.01228.x

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The retina is under constant threat of phototoxicity. Herein, we demonstrate that ascorbate (AscH) does not affect rose bengal-induced phototoxicity to ARPE-19 cells cultured in medium without iron supplement. In case of cells cultured in iron-supplemented medium, ascorbate exhibited protective effects at concentrations 0.35–0.70 mm during irradiation time of 20 min, but at longer irradiation time these concentrations of ascorbate exacerbated phototoxicity. Ascorbate at concentration of 1.4 mm exacerbated phototoxicity already for 20 min exposure. α-Tocopherol (TOH), particularly in combination with zeaxanthin (Zea), increased protective effects of ascorbate, but did not ameliorate the ascorbate-mediated increase in phototoxicity.

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