María C. García Vior, Julieta Marino, Leonor P. Roguin, Alejandro Sosnik and Josefina Awruch Photodynamic Effects of Zinc(II) Phthalocyanine-Loaded Polymeric Micelles in Human Nasopharynx KB Carcinoma Cells Photochemistry and Photobiology 89
Article first published online: 18 SEP 2012 | DOI: 10.1111/j.1751-1097.2012.01229.x
Zinc(II) phthalocyanine-loaded polymeric micelles generated singlet molecular oxygen in high yields. Photocytotoxicity assays using human nasopharynx KB carcinoma cells confirmed that the encapsulation of zinc(II) phthalocyanine in the polymeric micelles T1107 and T1307, increases its photocytotoxicity by 10 times in comparison with the free form in water–DMSO. A lysosomal localization was observed.
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